Nayem was born in Barisal, Bangladesh. She completed a Bachelor of Dental Surgery (BDS) at Dhaka City Dental College, a private medical college, to become a dentist.
Besides modeling, Nayem works in TV. and film. She established her acting career by working on the movie Run Out. She acted in Bangla drama Ghat Babu Nitai Candra in 2013 which was based on Sunil Gangopadhyay's novel Ghat Babu. She performed in an item song. She was signed to appear in upcoming film Maruf Taka Dhorena.
Naila used social media to promote herself although according to her, she never thought of using Facebook. She was hired as the campaign image of Foodpanda. She performed an item song in the movie Run Out. She performed on Ananta Jolil in a programme organized by Grameenphone. In 2015 she starred in an award-winning commercial by Bagher Bachcha Digital for LG electronics. Her commercial with Bangladeshi cricketer Sabbir Rahman, promoting a non-alcoholic malt beverage, was banned by the Bangladesh Cricket Board. She starred in a web series called The List by CMV.